Posted by Physicians Preference Vitamins on 8/16/2022 to Health and Wellness
It goes without saying that we all want to live a long, healthy life. It’s important to age well so that you can always feel your best. Merriam-Webster Dictionary defines longevity as a long duration of individual life. Lifespan refers to the length of time a person lives and healthspan is the time period of a person’s life when they are in good health.
When we look back at history, life expectancy has increased rapidly since the Age of Enlightenment in the 17th and 18th centuries. In the early 19th century, life expectancy started to increase in the early industrialized countries while it stayed low in the rest of the world. Since 1900, the global average life expectancy has more than doubled and is now above 70 years. The inequality of life expectancy is still very large across and within countries. In 2019 the country with the lowest life expectancy was the Central African Republic with 53 years, while in Japan life expectancy was 30 years longer. (1)
Research on therapies for lengthening both lifespan and healthspan has skyrocketed in recent years. There a handful of cutting-edge nutritional supplements that are exceptionally promising. Because they target various cellular pathways involved in aging, these supplements are an excellent adjunct to rapamycin, intermittent fasting and other therapies.
Our Longevity Pak provides you with easy-to-use packets of the highest-quality supplements that can help with increasing your healthspan. Each packet, which is to be taken once a day, includes:
NMN: Nicotinamide mononucleotide (NMN) increases levels of NAD+, a vehicle for energy production and an important regulator of cellular function. Levels of NAD+ decline as we age. Restoring them may help slow some of the processes associated with aging.
As the elderly population has been progressively rising in the world, the demand for anti-aging heath products to assure longevity, as well as to improve age-related complications, is also on the rise. Among various anti-aging health products, nicotinamide mononucleotide (NMN) has been gaining the attention of the consumers and the scientific community. Research shows that NMN, as the precursor of NAD+, has been seen to likely reverse these age-related complications and slow down the rate of aging by enhancing NAD+ levels in the body. (2)
Nicotinamide adenine dinucleotide (NAD+) levels in the body deplete with age and it is associated with downregulation of energy production in mitochondria, oxidative stress, DNA damage, cognitive impairment and inflammatory conditions. (2) By middle age, our NAD+ levels have plummeted to half that of our youth. Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan. NAD+ levels can be increased by supplementing with NAD precursors, including nicotinamide mononucleotide (NMN). (3)
Research shows that supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Supplementing with NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions. (3)
Betaine: Betaine is important to take along with NMN, as it replenishes methyl groups (small molecules that activate or inactivate targeted genes) that may be lost during the metabolism of NMN.
Resveratrol: The “red wine pill” is a potent antioxidant and anti-inflammatory that mimics some of the positive effects of calorie restriction and intermittent fasting. It has proven benefits for cardiovascular health and been shown to extend longevity in animals by 20%.
Resveratrol, found naturally in grape skins and red wines, possesses diverse health benefits ranging from chemoprevention to cardioprotection. Several studies describe resveratrol as an anti-aging compound. It appears that resveratrol can induce the expression of several longevity genes and prevent age-related decline in cardiovascular function, including cholesterol level and inflammatory response. Resveratrol acts like a miracle compound, which can protect the cells from many degenerative diseases including cardiovascular complications and cancer. (4)
Berberine: Berberine activates AMPK, an important energy sensing pathway. In addition to increasing insulin sensitivity and lowering blood sugar, berberine stimulates the production of new mitochondria for enhanced energy.
Quercetin: Known for its immune-boosting and anti-inflammatory effects, quercetin was recently shown to reduce senescent (old, damaged) cells in fat tissue.
Quercetin, the major flavonol found in several fruits and vegetables, is a natural antioxidant with potential anticancer and anti-aging activities. Research showed that quercetin increased 60% chronological life span. (5)
Fisetin: Fisetin also helps remove senescent cells, plus it has anti-inflammatory, antioxidant, anticancer, neuroprotective and cardioprotective properties.
Fisetin is a dietary flavonoid found in various fruits (strawberries, apples, mangoes, persimmons, kiwis, and grapes), vegetables (tomatoes, onions, and cucumbers), nuts, and wine that has shown strong anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects in cell culture and in animal models relevant to human diseases. (6)
Of 10 flavonoids tested in a research study, fisetin was the most potent senolytic (clearing out old, aged cells that can lead to disease). Fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit. (7)
Spermidine: Like Rapamycin, this anti-aging compound triggers autophagy, the cellular process that cleans out damaged cells, which enables cellular regeneration.
Spermidine is found in foods such as wheat germ, soybeans, nuts, and some fruits and vegetables and is produced by the microbiota. Increased intake of spermidine has protective effects against cancer, metabolic disease, heart disease, and neurodegeneration. (8)
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Call our Certified Holistic Nutritionists and Vitamin Consultants at 281-646-1659 or visit www.PhysiciansPreferenceVitamins.com to order your Longevity Pak today!